Obesity, metabolic health and omics: Current status and future directions

Table 4 Proteins with altered expression in metabolically healthy obese compared to metabolically unhealthy obese individuals

Biological material	Over-expressed	Under-expressed	Top enriched pathways	Ref.
Serum	APOB, AHSG, SERPINC1, APOA4, SERPING1, RBP4, ITIH2, GSN, HRG, ITIH1, GC, C7	HBA1, HPR, HBB, CFB, ITIH4, CRP, PON1, C4A	LXR/RXR activation, FXR/RXR activation, acute phase response signaling, complement system, atherosclerosis signaling, IL-12 signaling and production in macrophages, production of nitric oxide and reactive oxygen species in macrophages, clathrin-mediated endocytosis signaling, extrinsic prothrombin activation pathway, intrinsic prothrombin activation pathway, coagulation system	Doumatey et al[58]
Urine	RASN, IGHG2, K1C10, VTDB	ACOT2, ARL15, APC4, APC7, APOA1, DYH3, FIBA, C1GLT, HIX, ITIH4, KNG1, P3H2, AMBP, COO33, RET4, TRFE, ZFP2, ZN568, ZN655	LXR/RXR activation, FXR/RXR activation, acute phase response signaling, clathrin-mediated endocytosis signaling, atherosclerosis signaling, IL-12 signaling and production in macrophages, coagulation system, intrinsic prothrombin activation pathway, production of nitric oxide and reactive oxygen species in macrophages, systemic lupus erythematosus signaling	Benabdelkamel et al[59]
VAT	ANXA5, ACTG, ACTB, LEG1, GPDA, APOA1, CO6A1, SBP1, CATA, TO20L, BRE1A, RNA58, SOX21	POTEE, SPTN4, GDIR1, TTHY, HSP1, PPIA, UPAR, PAI1, BLVRB, ERI2, YQ019	death receptor signaling, coagulation system, acute phase response signaling, RhoGDI signaling, NRF2-mediated oxidative stress response	Alfadda et al[60]

IL: Interleukin; VAT: Visceral adipose tissue; LXR: Liver X receptor; RXR: Retinoid X receptor, FXR: Farnesoid X receptor; NRF2: Nuclear factor erythroid 2-related factor 2; RhoGDI: Rho GDP-dissociation inhibitor.