Obesity, metabolic health and omics: Current status and future directions

Table 3 Different expression of micro-RNAs identified in metabolically healthy obese individuals

miRNA	Upregulation/ Downregulation	Sample size (MHO/MHNW)	Biological material	Ref.
MHO vs MHNW
hsa-miR-5001	↓	6/6	Plasma	Yang et al[47]
hsa-miR-4541	↓
hsa-miR-142	↓
hsa-miR-320a1	↓
hsa-miR-107	↓
hsa-miR-34a	↑
hsa-miR-211	↑
hsa-miR-99b	↑
hsa-miR-148a1	↑
hsa-miR-1261	↑
MHO vs MUO
hsa-miR-223-3p	↓	10/10	Serum	Doumatey et al[48]
hsa-miR-374a-5p1	↑
hsa-miR-10b-5p	↑
hsa-miR-26b-5p	↑
hsa-let-7d-3p	↑
hsa-miR-29a-3p	↑
hsa-miR-342-3p	↑
hsa-miR-16-2-3p	↑
hsa-miR-503	↑	34/21	Serum	Yue et al[49]

¹Validated with real-time reverse transcription polymerase chain reaction in an independent cohort. miRNA: Micro-RNAs; MHO: Metabolically healthy obese; MHNW: Metabolically healthy normal weight; MUO: Metabolically unhealthy obese.