Feasibility of large experimental animal models in testing novel therapeutic strategies for diabetes

Table 2 Use of pigs as biomedical research subjects

	Advantages
1	Similar body size, shape, and anatomy as that of humans
2	Human-relevant metabolic physiology and pathophysiology
3	Monogastric omnivore
4	Multiparity, short gestation, short generation interval, and long-life cycle
5	Pancreatic and islet architecture similar to that of humans
6	Can undergo the same surgical procedure as in humans
7	Tools for genetic alterations are available
8	High litter size makes the production of genetically modified pigs less time-consuming in comparison with other livestock species
	Disadvantages
1	Specialized facilities are required
2	Costly to maintain
3	Ethical issues associated with the use of pigs in biomedical research