Copyright
©The Author(s) 2021.
World J Diabetes. Apr 15, 2021; 12(4): 306-330
Published online Apr 15, 2021. doi: 10.4239/wjd.v12.i4.306
Published online Apr 15, 2021. doi: 10.4239/wjd.v12.i4.306
Table 1 Hurdles in clinical islet transplantation for type 1 diabetes mellitus
| Hurdles in clinical islet transplantation for type 1 diabetes mellitus | |
| 1 | Poor access to human islets due to the scarcity of organ donors |
| 2 | Graft failure (e.g., metabolic pressure, oxidative stress caused by hypoxia or inflammation) |
| 3 | Continued autoimmunity and alloimmunity |
| 4 | Immunosuppressive drug therapy |
| 5 | Behavior of the transplanted cells in the growing body for transplantations performed in adolescents/children |
- Citation: Nagaya M, Hasegawa K, Uchikura A, Nakano K, Watanabe M, Umeyama K, Matsunari H, Osafune K, Kobayashi E, Nakauchi H, Nagashima H. Feasibility of large experimental animal models in testing novel therapeutic strategies for diabetes. World J Diabetes 2021; 12(4): 306-330
- URL: https://www.wjgnet.com/1948-9358/full/v12/i4/306.htm
- DOI: https://dx.doi.org/10.4239/wjd.v12.i4.306