Profilin-1 is involved in macroangiopathy induced by advanced glycation end products via vascular remodeling and inflammation

Figure 3 Expression of profilin-1 in the thoracic aortas of advanced glycation end products-injected rats. A-C: Western blot analysis and real-time PCR detection of the expression of the profilin-1 protein and mRNA, respectively, in the thoracic aorta. n = 3, ^aP < 0.05 compared with the control group, ^bP < 0.01 compared with the control group; D: Immunohistochemical staining revealing the expression of the profilin-1 protein in the thoracic aorta. Under a microscope at 200 × magnification, the profilin-1 protein was stained brown using the SABC immunohistochemical method, n = 3. AGEs: Advanced glycation end products.