Profilin-1 is involved in macroangiopathy induced by advanced glycation end products via vascular remodeling and inflammation

Table 2 Media thickness, lumen diameter, media thickness/lumen diameter, medial area, lumen area, medial area/lumen area, and smooth muscle layers of the thoracic aorta

	Control (n = 6)	AGEs-20 (n = 6)	AGEs-40 (n = 6)	AGEs-60 (n = 6)
MT (mm)	45.83 ± 3.54	57.17 ± 3.25a	74.83 ± 4.62a	79.33 ± 3.08a
LD (mm)	737.5 ± 9.89	769.83 ± 15.73a	862.33 ± 21.99a	857.67 ± 15.06a
MT/LD (%)	6.21 ± 0.41	7.42 ± 0.35a	8.67 ± 0.37a	9.25 ± 0.34a
MA (mm2)	0.53 ± 0.01	0.54 ± 0.01a	0.55 ± 0.01a	0.56 ± 0.01a
LA (mm2)	1.97 ± 0.04	1.85 ± 0.04a	1.67 ± 0.04a	1.64 ± 0.04a
MA/LA (%)	26.97 ± 0.38	29.16 ± 0.73a	32.99 ± 0.79a	34.13 ± 0.62a
SML (layer)	6.17 ± 0.75	7.17 ± 0.73	7.67 ± 0.82b	8.17 ± 0.75b

^aP < 0.05 compared with the control group.

^bP < 0.01 compared with the control group.

AGEs: Advanced glycation end products; MT: Media thickness; LD: Lumen diameter; MA: Media area; LA: Lumen area; SML: Smooth muscle layers.