Metabolic and inflammatory functions of cannabinoid receptor type 1 are differentially modulated by adiponectin

Figure 4 Cannabinoid type 1 receptor-null mice have reduced peritoneal and adipose tissue inflammation. Wild-type (WT) and cannabinoid type 1 receptor-null (CB1^-/-) male mice at 8 mo of age. A: Flow cytometry analysis of M1 and M2 in peritoneal macrophages; B: Percentage of epididymal fat depot; C: Flow cytometry analysis of M1 and M2 in epididymal fat; D: Pro-inflammatory cytokines expression in epididymal fat. n = 6-8. ^aP < 0.05, ^bP<0.001, WT vs CB1^-/- mice.