Metabolic and inflammatory functions of cannabinoid receptor type 1 are differentially modulated by adiponectin

Figure 3 Double-knockout mice have similar expression of thermogenic genes compare to cannabinoid type 1 receptor-null mice. Wild-type (WT) and cannabinoid type 1 receptor-null (CB1^-/-) male mice at 8 mo of age. A: Brown adipose tissue (BAT) weight and percentage of BAT depot; B: Quantitative real-time RT-PCR analysis of gene expression in BAT. Cannabinoid type 1 receptor-null (CB1^-/-) and double-knockout (DKO) male mice at 8 mo of age. C: BAT weight and percentage of BAT depot; D: Quantitative real-time RT-PCR analysis of gene expression in BAT. n = 6-8. ^aP < 0.05, ^bP < 0.001, WT vs CB1^-/- or CB1^-/- vs DKO.