Glycemic targets in critically ill adults: A mini-review

Table 3 Glycemic targets in intensive care unit by casemix and variability

Casemix	Blood sample	Method	Glycemic target	Evidence
Medical-surgical	Arterial, venous	Glucometer	Glucose variability (COV ≥ 20%)	Increased ICU and hospital mortality in patients without DM; Obs[26]
Medical-surgical	Arterial, capillary	Glucometer or blood gas analyzer	Glucose variability > 6 mmol/L	Increased ICU and hospital mortality; Obs[44]
Medical-surgical	Arterial	Glucometer or blood gas analyzer	Glucose variability > 4 mmol/L	Increased hospital mortality; Obs[10]
Post-CA	Arterial	Blood gas analyzer	Glucose variability < 5 mmol/L	Decreased hypoglycemia and mortality; Obs[45]
Post-CA	Not stated	Not stated	GG-min < 3.9 mmol/L	Better neurological recovery; Obs[95]

COV: Coefficient of variation; GG: Glycemic gap; GG-min: Minimum glycemic gap = minimum blood glucose - [(1.59 × HbA1c) - 2.59], HbA1c being used to estimate average glucose concentration over the prior 3 mo; ICU: Intensive care unit; Obs: Observational study.