Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity

Figure 7 Inhibition of basal and insulin-stimulated hexose uptake in rat adipocytes by high doses of the α₁-adrenoreceptors antagonist prazosin and the α₂-adrenoreceptors antagonist methoxy-idazoxan. Rat fat cells were incubated for 45 min with the indicated concentrations of agents without (control, closed columns), and with 1 mmol/L prazosin (open columns) or 0.1 mmol/L RX 821002 (shaded columns) prior to 2-deoxyglucose uptake, expressed as the fold increase relative to basal. The mean ± SE of 4 separate experiments performed in the presence of 100 µmol/L vanadate was determined. Significant difference between the inhibitor and the respective control was observed at: ^aP < 0.05. 2-DG: 2-Deoxyglucose.