Development of therapeutic options on type 2 diabetes in years: Glucagon-like peptide-1 receptor agonist’s role intreatment; from the past to future

Table 2 Cardiovascular effect of glucagon like peptide-1 receptor agonists

Anti-atherosclerotic effect	Decrease matrix metalloproteinase 2; decrease vascular smooth muscle cell proliferation
Improves endothelial function	Increase nitric oxide-induced vasodilation; decrease oxidative stress
Anti-inflammatory effect	Suppress human macrophagesby inhibition of protein kinase C
Decrease infarct/injury size	Decrease glucose-induced apoptosis; decrease intracellular calcium overload
Modifies risk factors	Improve glycemic control; decrease body weight; decrease blood pressure; decrease low-density lipoprotein