SGLT-2 inhibitors in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: A systematic review

doi:10.4239/wjd.v10.i2.114

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Feb 15, 2019 (publication date) through May 7, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Systematic Reviews

World J Diabetes. Feb 15, 2019; 10(2): 114-132
Published online Feb 15, 2019. doi: 10.4239/wjd.v10.i2.114

Table 11 Change in fasting plasma glucose in individual studies

Study	Fasting plasma glucose (mg/dL)			P value	P value between groups
Study	Group	Baseline	Study completion	P value	P value between groups
Kuchay et al[11]	Empagliflozin	173.0 (44.0)	124.0 (17.0)	< 0.001	0.85
Kuchay et al[11]	Control	176.0 (57.0)	120.0 (19.0)	< 0.0001	0.85
Ito et al[12]	Ipragliflozin	160.1 (38.7)	136.5 (26.7)	< 0.05	0.785
Ito et al[12]	Pioglitazone	169.4 (50.9)	139.0 (26.6)	< 0.05	0.785
Shibuya et al[13]	Luseogliflozin	127.0 (116.0, 136.0)	125.0 (113.0, 138.0)	0.87	0.583
Shibuya et al[13]	Metformin	147.0 (126.0, 161.0)	134.0 (122.0, 145.0)	0.32	0.583
Eriksson et al[14]	Placebo	169.2 (29.7)	+6.7 (14.8)¹	-	-
	Omega-3 CA	162.4 (26.6)	+3.8 (19.3)¹	-	Non-significant²
	Dapagliflozin	161.8 (33.3)	-17.6 (26.8)¹	-	< 0.05²
	O + D	168.8 (35.5)	-16.4 (36.0)¹	-	< 0.05²
Ohki et al[15]	Ipragliflozin	162.0 (135.0-189.0)	135.0 (120.0-166.0)	0.3	-
Seko et al[16]	SGLT-2 inhibitor	125.0 (6.0)	116.6 (4.2)	0.07	Non-significant
Seko et al[16]	Sitagliptin	114.6 (7.0)	134.0 (10.5)	0.067	Non-significant
Sumida et al[18]	Luseogliflozin	142.0 (30.3)	135.4 (25.6)	0.04	-

¹Change from baseline.

²Compared to placebo.

CA: Carboxylic acid; O + D: Omega-3 carboxylic acid + Dapagliflozin; SGLT-2: Sodium glucose cotransporter-2.

Citation: Raj H, Durgia H, Palui R, Kamalanathan S, Selvarajan S, Kar SS, Sahoo J. SGLT-2 inhibitors in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: A systematic review. World J Diabetes 2019; 10(2): 114-132
URL: https://www.wjgnet.com/1948-9358/full/v10/i2/114.htm
DOI: https://dx.doi.org/10.4239/wjd.v10.i2.114