Review
Copyright ©The Author(s) 2019.
World J Diabetes. Jan 15, 2019; 10(1): 1-15
Published online Jan 15, 2019. doi: 10.4239/wjd.v10.i1.1
Table 1 Characteristics of the analytical methods for hemoglobin A1c measurement
MethodAdvantagesDisadvantages
Ion exchange chromatographyDCCT method, high reproducibilityLack of specificity; interference from hemoglobinopathies and HbF
Capillary electrophoresisHigh reproducibility; specificityTime-consuming, costly
Boronate affinity chromatographyMinimal interference from hemoglobinopathiesAnalyte-related unspecificity (total GHb)
ImmunoassaySpecificitySome interference from HbF