Original Article
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastrointest Endosc. Sep 16, 2014; 6(9): 419-431
Published online Sep 16, 2014. doi: 10.4253/wjge.v6.i9.419
Table 10 Implantable Gastric Stimulator Transcend® outcomes
Weight, kgAverage Weight loss, kg (%)-In the treatment group compared to baseline weight
Hunger reduction/ Reduced appetiteOther statistically significant or important negative results3
BaselineAt 3 mo ± 2 wkAt 6 mo ± 2 wkAt 12 mo ± 3 moBeyond 12 mo
I1[28]113.1-7.0 (-6.2%), P < 0.05-5.5 (-4.9%), P < 0.05-2.1 (-1.9%), P < 0.05 at 24 moIn control group, weight gain despite IGS activation from 12 to 24 mo
No significant change in fasting ghrelin or Peptide YY levels
I2[21]NRNo significant weight loss observed
I3[73]112.5-2 (-1.8%) NS+3.5 (+3.1%) NSNo significant weight loss observed
I4[29]92%EWL = 5.9%
I5[30]116%EWL = 14%%EWL = 19%%EWL = 20%%EWL = 25%
I6[20]129%EWL = 1.3% (study group); 2.4% (control) NSMean %EWL = 2.5%%EWL = 20% at 29 mo1Only a subset (23%) of patients lost significant amount of weight (> 5% EWL)
(P value NR)
I7[20]NR%EWL > 10% in 54% of subjects; > 20% in 23%%EWL = 23% at 16 moYes2, P = 0.0433Satiety increased between and at the end of meals
I8[32]132.7± 27.3%EWL for 2 yr period for each cohort = 20%-40%Lower blood pressure
I9[74]115%EWL = 16.3%%EWL = 16.9%%EWL = 23.8% at 10 moYesSatiety increased between and at the end of meals
-8.2 (-7.11%), P = 0.0011-8.4 (-7.29%), P = 0.0310-11.7 (-10.1%), P = 0.0112
I10[36]115%EWL = 15.8%%EWL = 17.8%%EWL = 21.0% at 10 mo%EWL = 21.0% at 15 moYesSatiety increased between and at the end of meals
No significant change in ghrelin level
I11[75]121.7± 5.1-10.4 (-8.5%), P < 0.01Reduced meal-related CCK response
Lower basal and meal-related somatostatin level
Lower basal GLP-1 level (Not meal-related)
Lower basal leptin level (Not meal-related)
I12[35]NR-2.7%, P = 0.03Significant weight loss at 12 mo was observed after procedural corrections
I13[76]122.2%EWL = 17.8%%EWL = 18.6%EWL 30.2 at 9 mo
-9.4 (-7.7%)-10.0 (-8.2%)-16.0 (-13.1%)
(P value NR)(P value NR)(P value NR)