Endoscopic ultrasonography for surveillance of individuals at high risk for pancreatic cancer

Table 1 Genetic diseases associated with pancreatic cancer risk

Risk condition	Relative risk	Risk by age 70	Gene
Familial pancreatic cancer			PALLD
1 first-degree relative	2.3-4.5	2%	BRCA2
2 first-degree relatives	6.4-18	3%	PALB2
≥ 3 first-degree relatives	32-57	16%
Familial atypical multiple mole melanoma	13-38	15%-20%	CDKN2A/p16
Peutz-Jeghers Syndrome	132	11%-60%	STK11/LKB1
Hereditary pancreatitis	50-87	30%-75%	PRSS1
			PRSS2
			SPINK1
			CTRC
Cystic fibrosis	5.3	<5%	CFTR
Familial breast ovarian cancer	3.5-10	5%	BRCA2
	2.3-3.6	1%	BRCA1
Hereditary non-polyposis colon cancer	2.3-8.6	3%-4%	MLH1
			MSH2
			MSH6
Familial adenomatous polyposis	4.5-5	2%	FAP
			MUTYH
Li Fraumeni sindrome	Unknown	Unknown	TP53