Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy

Table 4 Diagnostic accuracy of immunohistochemistry, alone or in selected combinations, as applied only to cytologically benign, atypical and suspicious specimens

	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	PLR	NLR
p53	17	100	100	33	¥	0.83
Ki-67	21	100	100	34	¥	0.79
CEA	52	42	68	26	1	1.16
CA19-9	48	75	82	38	2	0.69
p53 + Ki-67	28	100	100	36	¥	0.72
p53 + Ki-67 + CEA	66	42	73	33	1	0.83
p53 + Ki-67 + CA19-9	66	75	86	47	3	0.46
All 4 stains	76	42	76	42	1	0.58

CEA: carcinoembryonic antigen; IH: immunohistochemistry; NLR: negative likelihood ratio; NPV: negative predictive value; PLR: positive likelihood ratio; PPV: positive predictive value.