From surface to depth: Combining white-light and ultrasound endoscopy to predict complete response in rectal cancer

Figure 1 Representative white light endoscopy and endoscopic ultrasound images at response assessment. A: White light endoscopy (WLE) image displaying endoscopic CR (eCR) morphology, characterized by a flat white scar with telangiectasia, no ulceration, and no nodularity; B: WLE image displaying near-eCR morphology, mild mucosal irregularity and superficial ulceration without obvious tumor mass; C: WLE image displaying non-eCR morphology, with visible exophytic or ulcerative tumor lesion at the original tumor site; D: Endoscopic ultrasound (EUS) image displaying completely restored wall layers, showing clear, distinct, and continuous anatomical layers; E: EUS image displaying partially restored layers, demonstrating some focal structural disruption or thickening but with visible layer structures; F: EUS image displaying mass echo pattern, presenting as a distinct hypoechoic lesion disrupting the normal wall layers.