From surface to depth: Combining white-light and ultrasound endoscopy to predict complete response in rectal cancer

doi:10.4253/wjge.122124

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

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World J Gastrointest Endosc. Aug 16, 2026; 18(8): 122124
Published online Aug 16, 2026. doi: 10.4253/wjge.122124

Table 1 Baseline of enrolled patients, n (%)

	All	CR	Non-CR	P value
Total	145	35	110
Sex				0.633
Male	100 (69.0)	23 (65.7)	77 (70.0)
Female	45 (31.0)	12 (34.3)	33 (30.0)
Age, median (IQR), year	58 (51.5-65.5)	56 (51-65)	58 (51.3-66)	0.65
Location				0.035
Proximal	34 (23.4)	3 (8.6)	31 (28.2)
Middle	80 (55.2)	21 (60.0)	59 (53.6)
Distal	31 (21.4)	11 (31.4)	20 (18.2)
Histology				0.801
Well/moderate	125 (85.5)	31 (88.6)	93 (84.5)
Poor	17 (11.7)	3 (8.6)	14 (12.7)
Special	4 (2.8)	1 (2.9)	3 (2.7)
cT				< 0.001
cT2	11 (7.6)	8 (22.9)	3 (2.7)
cT3	83 (57.2)	23 (65.7)	60 (54.5)
cT4	51 (35.2)	4 (11.4)	47 (42.7)
cN				0.361
cN0	22 (15.2)	7 (20.0)	15 (13.6)
cN⁺	123 (84.8)	28 (80.0)	95 (86.4)
cM				1
cM0	141 (97.2)	34 (97.1)	107 (97.3)
cM⁺	4 (2.8)	1 (2.9)	3 (2.7)
Pre-nCRT level of CEA, median (IQR), ng/mL	4.84 (2.48-12.59)	2.72 (1.74-9.15)	5.5 (2.64-15.04)	0.019
Post-nCRT level of CEA, median (IQR), ng/mL	2.42 (1.57-4.14)	2.28 (1.54-3.54)	2.49 (1.57-4.42)	0.32
Interval C/RT to endoscopy, median (IQR), weeks	9 (7-10)	9 (7-11)	8 (7-10)	0.207
Interval endoscopy to surgery, median (IQR), weeks¹	3 (2-5)	5 (2-6)	3 (2-5)	0.094

¹Data in patients undergoing surgery.

CR: Complete response; nCRT: Neoadjuvant chemoradiotherapy; CEA: Carcinoembryonic antigen; IQR: Interquartile range.

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Citation: Chi J, Weng J, Li WH, Bai KH, Yang R, Zhang LJ, Fan WH, Wu XJ. From surface to depth: Combining white-light and ultrasound endoscopy to predict complete response in rectal cancer. World J Gastrointest Endosc 2026; 18(8): 122124
URL: https://www.wjgnet.com/1948-5190/full/v18/i8/122124.htm
DOI: https://dx.doi.org/10.4253/wjge.122124

Chi J, Weng J, Li WH, Bai KH, Yang R, Zhang LJ, Fan WH, Wu XJ. From surface to depth: Combining white-light and ultrasound endoscopy to predict complete response in rectal cancer. World J Gastrointest Endosc 2026; 18(8): 122124 [DOI: 10.4253/wjge.122124]

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