Celiac disease onset and inflammatory milieu

doi:10.4253/wjge.118718

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Endosc. Aug 16, 2026; 18(8): 118718
Published online Aug 16, 2026. doi: 10.4253/wjge.118718

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Figure 5 A model of celiac disease onset. The top panel shows that various combinations of inflammatory load thresholds for the quantitative/affinity vs loss of tolerance models may occur. As inflammatory load increases in the tolerant individual (lower panel), regardless of the threshold levels (top panel) the balance will be tipped toward disease onset, so that oral tolerance may be breached.

Citation: Ciaccio EJ, Wolf RL, Ciacci C, Green PH, Acharya UR. Celiac disease onset and inflammatory milieu. World J Gastrointest Endosc 2026; 18(8): 118718
URL: https://www.wjgnet.com/1948-5190/full/v18/i8/118718.htm
DOI: https://dx.doi.org/10.4253/wjge.118718

Ciaccio EJ, Wolf RL, Ciacci C, Green PH, Acharya UR. Celiac disease onset and inflammatory milieu. World J Gastrointest Endosc 2026; 18(8): 118718 [DOI: 10.4253/wjge.118718]

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