Polyposis in Lynch syndrome: A retrospective study

Table 3 Participants with ≥ 6 colonoscopies, stratified by number of adenomas (< 10, ≥ 10)

	Participants with ≥ 6 colonoscopies (n = 92)
	< 10 lifetime adenomas (n = 81)	≥ 10 lifetime adenomas (n = 11)	P value
Age at first colonoscopy, year, mean ± SD (range)	47.1 ± 12.5 (20-72)	48.9 ± 13.6 (26-75)	0.51
Sex			0.33
Male	25 (30.9)	6 (54.5)
Female	56 (69.1)	5 (45.5)
Race			0.70
White	73 (90.1)	10 (90.9)
Black	5 (6.2)	1 (9.1)
Hispanic	1 (1.2)	0 (0.0)
Asian	1 (1.2)	0 (0.0)
Native American	1 (1.2)	0 (0.0)
Current smoker	9 (11.3)	1 (9.1)	1.00
BMI in kg/m2, mean ± SD (range)	27.9 ± 5.9 (18-50)	29.7 ± 6.2 (18.7-38.4)	0.38
First-degree relative with CRC, yes	45 (55.6)	7 (63.6)	0.75
Second-degree relative with CRC, yes	47 (58.8)	6 (54.6)	1.00
Medication use
Aspirin use (yes)	18 (22.2)	3 (27.3)	0.71
Statin use (yes)	7 (8.6)	2 (18.2)	0.29
NSAID use (yes)	11 (13.6)	2 (18.2)	0.65
Affected gene			0.28
EPCAM	1 (1.2)	0 (0.0)
MLH1	18 (22.2)	0 (0.0)
MSH2	29 (35.8)	5 (45.5)
MSH6	20 (24.7)	5 (45.5)
PMS2	13 (16.1)	1 (9.1)
Diagnosis of CRC, yes	43 (53.1)	5 (45.5)	0.75
Age at CRC diagnosis in years, mean ± SD (range)	48.6 ± 12.0 (24-70)	52.6 ± 17.5 (35-80)	0.80
Colectomy			1.00
Partial	25 (30.9)	2 (18.2)
Sub-total/total	12 (14.8)	1 (9.1)
None	44 (54.3)	8 (72.7)
Age at first polyp in years, mean ± SD (range)	49.7 ± 11.9 (22-70)	50.7 ± 14.9 (27-80)	0.87
Number of colonoscopies, mean ± SD (range)	8.1 ± 2.3 (6-16)	11.2 ± 4.7 (6-23)	0.01
Number of adenomas, mean ± SD (range)	2.7 ± 2.2 (0-9)	18.7 ± 12.3 (10-44)	< 0.0001
Time followed in years, mean ± SD (range)	12.2 ± 6.7 (4-36)	13.1 ± 5.4 (5-26)	0.23

CRC: Colorectal cancer; NSAID: Non-steroidal anti-inflammatory drug.