Polyposis in Lynch syndrome: A retrospective study

Table 1 Characteristics of the study population

	Total cohort (n = 257)
Age at first colonoscopy, year, mean ± SD (range)	45.5 ± 14.3 (19-87)
Sex
Male	89 (34.6)
Female	168 (65.4)
Race
White	245 (95.3)
Black	7 (2.7)
Hispanic	1 (0.4)
Asian	3 (1.2)
Native American	1 (0.4)
Current smoker	40 (15.6)
BMI in kg/m2, mean ± SD (range)	28.8 ± 6.4 (17.4-53.9)
First-degree relative with CRC, yes	134 (52.1)
Second-degree relative with CRC, yes	148 (58.0)
Medication use
Aspirin use (yes)	50 (19.5)
Statin use (yes)	32 (12.5)
NSAID use (yes)	43 (16.7)
Affected gene
EPCAM	2 (0.8)
MLH1	51 (19.8)
MSH2	90 (35.0)
MSH6	64 (24.9)
PMS2	50 (19.5)
Diagnosis of CRC, yes	88 (34.2)
Age at CRC diagnosis in years, mean ± SD (range)	49.6 ± 13.5 (24-87)
Colectomy
Partial	50 (19.5)
Sub-total/total	28 (10.9)
None	179 (69.6)
Age at first polyp in years, mean ± SD (range)	49.2 ± 13.4 (22-87)
Number of colonoscopies, mean ± SD (range)	4.7 ± 3.5 (1-23)
Number of adenomas, mean ± SD (range)	2.4 ± 4.6 (0-44)
Diagnosed with ≥ 10 adenomas, yes	11 (4.3)
Time followed in years, mean ± SD (range)	6.8 ± 6.7 (0-36)

BMI: Body mass index; CRC: Colorectal cancer; NSAID: Non-steroidal anti-inflammatory drug.