Expanding the therapeutic spectrum for duodenal adenomas: Cryoballoon ablation

doi:10.4253/wjge.v18.i6.117354

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Endosc. Jun 16, 2026; 18(6): 117354
Published online Jun 16, 2026. doi: 10.4253/wjge.v18.i6.117354

Table 2 Clinical advantages and appropriate indications of cryoballoon ablation

Potential advantages	Appropriate indications	Lesions unsuitable for CBA
Depth-limited uniform injury (reduced perforation risk)	Benign non-ampullary duodenal adenomas (Paris 0-IIa/IIb)	Bulky circumferential lesions (> 5 cm)
Preservation of submucosal collagen matrix	Recurrent or fibrotic (non-lifting) lesions	Suspected deep submucosal invasion
Non-thermal mechanism avoiding coagulative necrosis	Residual adenoma within scar tissue or near clips	Lesions requiring histologic margin assessment
Technically simple balloon-based delivery system	Lesions in angulated or technically challenging locations

CBA: Cryoballoon ablation.

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Citation: Seo JY, Yoo JH. Expanding the therapeutic spectrum for duodenal adenomas: Cryoballoon ablation. World J Gastrointest Endosc 2026; 18(6): 117354
URL: https://www.wjgnet.com/1948-5190/full/v18/i6/117354.htm
DOI: https://dx.doi.org/10.4253/wjge.v18.i6.117354

Seo JY, Yoo JH. Expanding the therapeutic spectrum for duodenal adenomas: Cryoballoon ablation. World J Gastrointest Endosc 2026; 18(6): 117354 [DOI: 10.4253/wjge.v18.i6.117354]

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