Eosinophilic esophagitis in children: Clinical perspectives and evolving therapeutic strategies

Table 2 Potential new biomarkers for disease activity monitoring in patients with eosinophilic esophagitis

Biomarker	Tissue specimen			Clinical utility	Evidence maturity (clinical use vs investigational)
	Mucosa	Blood	Feces
Eosinophil cationic protein	Yes	Yes	Yes	Disease activity monitoring, predict endoscopy severity, predict treatment response	Investigational
Eosinophil-derived neurotoxin	Yes	Yes	Yes	Disease activity monitoring, predict treatment response	Investigational
Eosinophil peroxidase	Yes	Yes	No	Disease activity monitoring, predict treatment response	Investigational
Major basic protein	Yes	Yes	No	Disease activity monitoring	Investigational
Mast cell tryptase	Yes	No	No	Disease activity monitoring	Investigational
Chemokine (C-C motif) ligand 26	Yes	Yes	No	Disease activity monitoring	Investigational
Periostin	Yes	No	No	Disease activity monitoring	Investigational
Microbiome	Yes	No	No	Disease activity monitoring	Investigational