Patient-selected music reduces propofol requirements during combined upper gastrointestinal endoscopy and colonoscopy: A prospective single-center study (MUSICENDO)

Table 2 Primary and secondary outcomes, n (%)

Characteristic	n	Music protocol (n = 44)	Standard care (n = 44)	Absolute difference (95%CI)	P value	P adjusted value
Primary outcome-modified intention-to-treat population
Propofol administered (mg/kg/minute)	88			-0.08 (-0.10 to -0.05)	< 0.0001	NA
mean ± SD		0.18 ± 0.05	0.26 ± 0.07
Median (interquartile range)		0.18 (0.16-0.20)	0.26 (0.21-0.32)
Secondary outcomes-modified intention-to-treat population
Serious adverse event				NA	NA	NA
Bronchospasm		0 (0.0)	2 (4.5)
Laryngospasm and intubation		1 (2.3)	0 (0.0)
Primary outcome – sensitivity analysis – per-protocol population
Propofol administered (mg/kg/minute)	82			-0.07 (-0.10 to -0.05)	< 0.0001	0.0009
mean ± SD		0.19 ± 0.05	0.26 ± 0.07
Median (interquartile range)		0.18 (0.17-0.20)	0.26 (0.21-0.32)
Secondary outcomes-per-protocol population
Examination duration (minutes)	82			1.24 (-1.09 to 3.58)	0.29	0.89
mean ± SD		20.44 ± 4.76	19.20 ± 5.82
Median (interquartile range)		19.00 (17.00-22.00)	19.00 (15.00-21.00)
Total ambulatory stay (minutes)	69			-0.44 (-7.00 to 6.12)	0.89	0.89
mean ± SD		82.22 ± 14.71	82.66 ± 12.59
Median (interquartile range)		81.00 (73.00-94.00)	80.50 (74.50-90.00)
Propofol administered (mg)	82			-86.64 (- 119.09 to -54.18)	< 0.0001	0.0009
mean ± SD		258.24 ± 57.52	344.88 ± 86.86
Median (interquartile range)		250.00 (216.00-283.00)	327.00 (297.00-375.00)
Propofol administered as vials	82			-0.17 (-0.24 to -0.11)	< 0.0001	0.0009
mean ± SD		0.52 ± 0.12	0.69 ± 0.17
Median (interquartile range)		0.50 (0.43-0.57)	0.65 (0.59-0.75)
PSi	81			3.50 (1.98 to 5.00)	< 0.0001	0.0009
mean ± SD		35.23 ± 3.43	31.73 ± 3.39
Median (interquartile range)		35.00 (34.00-37.50)	32.00 (30.00-34.00)
Difference between after and before intervention in SBP	78			-4.05 (-12.77 to 4.67)	0.36	0.89
mean ± SD		11.86 ± 19.18	15.91 ± 19.48
Median (interquartile range)		12.00 (-3.75-23.50)	13.25 (4.00-34.00)
Difference between after and before intervention in DBP	78			4.08 (-2.94 to 11.09)	0.25	0.89
mean ± SD		8.90 ± 15.51	4.82 ± 15.59
Median (interquartile range)		6.50 (-1.50-15.75)	5.00 (-4.50-14.00)
Difference between after and before intervention in PP	76			2.05 (-4.15 to 8.26)	0.51	0.89
mean ± SD		7.21 ± 14.32	5.16 ± 12.81
Median (interquartile range)		5.75 (1.84-15.25)	5.00 (-2.84-12.25)

DBP: Diastolic blood pressure; PP: Pulse pressure; PSi: Patient State index; SBP: Systolic blood pressure.