Endoscopic management of intestinal strictures in Crohn’s disease: Current status and future perspectives

doi:10.4253/wjge.123858

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Endosc. Oct 16, 2026; 18(10): 123858
Published online Oct 16, 2026. doi: 10.4253/wjge.123858

Table 4 Pivotal medical therapy trials in Crohn’s disease strictures

Trial	Design	n	Intervention	Primary success	Long-term
CREOLE (2018)	Prospective cohort	97	ADA	64% at week 24	29% prolonged success at 4 years; 51% surgery-free
STRIDENT (2021)	RCT (intensive vs standard)	77	Intensive ADA + thiopurine	Symptom improvement 79% (vs 64%) at 12 months	< 33% surgery at 4.5 years
Post-hoc biologics	Pooled	> 500	Anti-TNF, UST, VDZ	> 60% endoscopic response at 1 year	Reduced surgery

ADA: Adalimumab; RCT: Randomized controlled trial; TNF: Tumor necrosis factor; UST: Ustekinumab; VDZ: Vedolizumab.

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Citation: Mundhra SK, Singh AK, Kochhar R, Manrai M. Endoscopic management of intestinal strictures in Crohn’s disease: Current status and future perspectives. World J Gastrointest Endosc 2026; 18(10): 123858
URL: https://www.wjgnet.com/1948-5190/full/v18/i10/123858.htm
DOI: https://dx.doi.org/10.4253/wjge.123858

Mundhra SK, Singh AK, Kochhar R, Manrai M. Endoscopic management of intestinal strictures in Crohn’s disease: Current status and future perspectives. World J Gastrointest Endosc 2026; 18(10): 123858 [DOI: 10.4253/wjge.123858]

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