Beyond conventional endoscopy: Image-enhanced techniques in quiescent ulcerative colitis assessment

Table 1 Key performance metrics for each image-enhanced endoscopy modality compared to Mayo Endoscopic Score/Ulcerative Colitis Endoscopic Index of Severity

IEE modality	Interobserver agreement (κ or description)	Predictive HR (relapse)	Correlation with MES/UCEIS	Ref.
NBI	Good to excellent interrater reliability	Detects incomplete vascular regeneration (not specified)	Strong concordance with MES and histology	[20-23]
TXI	Moderate to good (κ = 0.597-0.823)	4.16 for TXI score 2 (high risk of relapse)	Strong correlation with MES and UCEIS	[24,25]
RDI	Superior to MES with strong expert/non-expert agreement	3.56 for RDI scores 3-4 (increased relapse risk)	Significant correlation with MES and UCEIS	[25-28]
LCI	Excellent interobserver agreement	Strong predictor, numeric HR not given	Strong correlation with MES and histology	[30-34]
iSCAN/PICaSSO	Excellent reproducibility	Comparable to MES/UCEIS in relapse prediction	Strong correlation with MES and UCEIS	[36-41]

IEE: Image-enhanced endoscopy; NBI: Narrow-band imaging; TXI: Texture and color enhancement imaging; RDI: Red dichromatic imaging; LCI: Linked-color imaging; PICaSSO: Paddington International virtual ChromoendoScopy ScOre; MES: Mayo Endoscopic Subscore; HR: Hazard ratio; UCEIS: Ulcerative Colitis Endoscopic Index of Severity.