Evolving role of endoscopic ultrasound in biliary stricture management: A meta-analysis and systematic review

Table 2 Characteristics of the included interventional studies

Ref.	Study design	Study setting	Study group	Sample size	Mean age (years)	Inclusion criteria	Reported outcomes	Center type
Bang et al, 2018[19]	RCT	United States	EUS-BD	33	69.4 ± 12.6	Patients with obstructive jaundice and a pancreatic head mass	Rate of adverse events, technical success, treatment success, re-interventions, and procedural duration	MC
Paik et al, 2018[20]	RCT	South Korea	EUS-BD	64	64.8	Adult patients with unresectable malignant biliary strictures	Technical success rates, clinical success rates, median hospital stay, and early adverse events	MC
Sharaiha et al, 2016[21]	Retrospective case-control study	United States	EUS-BD	47	-	Patients with either malignant or benign biliary obstruction	Technical and clinical success, post-procedural pain, and incidence of adverse events	SC
Bapaye et al, 2013[22]	Retrospective case-control study	India	EUS-BD	25	59.9 ± 13.3	Patients with unresectable malignancies causing biliary obstruction	Successful stent placement and incidence of complications	SC
Huang et al, 2017[23]	Retrospective case-control study	China	EUS-BD	36	68 ± 4.62	Patients with failed ERCP for the management of obstructive jaundice secondary to malignancy	Technical and clinical success rates, complications, and length of hospital stay	SC
Lee et al, 2016[24]	RCT	South Korea	EUS-BDS	34	66.5	Patients with distal MBOs	Technical and functional success, procedure-related adverse events, reintervention rate, and hospital stay	MC
Khashab et al, 2015[25]	Retrospective case-control study	UnitedStates	EGBD	64	64.9 ± 12.5	Patients with distal MBOs with at least one failed ERCP session	Adverse events, procedure-related costs, and reintervention rates	SC
Artifon et al, 2012[26]	RCT	Brazil	EUS-CD	13	63.4 ± 11.1	Patients with unresectable MBOs	Success rate, quality of life outcomes, and incidence of adverse events	SC
Bill et al, 2016[27]	Retrospective case–control study	United States	EUSr	25	65.4 ± 11.6	Patients with MDBO with a previous failed ERCP	Technical and clinical success, length of hospital stay, and repeat procedure rate	SC

RCT: Randomized controlled trial; EUS-BD: Endoscopic ultrasound-biliary drainage; MC: Multi-center ; SC: Surgical control; EUS-BDS: Endoscopic ultrasound-biliary drainages; EGBD: Endoscopy guided biliary drainage; EUS-CD: Endoscopic ultrasound-guided choledochoduodenostomy; MBOs: Malignant biliary obstructions; MDBO: Malignant distal biliary obstruction; ERCP: Endoscopic retrograde cholangiopancreatography.