Endoscopic insights into digestive-related adverse effects of immune checkpoint inhibitors: A narrative review

Table 1 Classification of upper gastrointestinal symptom severity according to the Common Terminology Criteria for Adverse Events

Condition	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Abdominal pain	Mild pain	Moderate pain; Limiting instrumental ADL	Severe pain; Limiting self-care ADL
Dysphagia	Symptomatic, able to eat a regular diet	Symptomatic and altered eating or swallowing	Severely altered eating/swallowing; Tube feeding, TPN, or hospitalization indicated	Life-threatening consequences; Urgent intervention indicated	Death
Vomiting	Intervention not indicated	Outpatient IV hydration; Medical intervention indicated	Tube feeding, TPN, or hospitalization indicated	Life-threatening consequences	Death
Upper GI hemorrhage	Mild symptoms; Intervention not indicated	Moderate symptoms; Intervention indicated	Transfusion indicated; Invasive intervention indicated; Hospitalization	Life-threatening consequences; Urgent intervention indicated	Death

GI: Gastrointestinal; ADL: Activities of daily living; IV: Intravenous; TPN: Total parenteral nutrition.