Endoscopic resection of colorectal laterally spreading tumors: Clinicopathologic characteristics and risk factors for treatment outcomes

Table 3 Subgroup comparison between patients with low-grade dysplasia and high-grade dysplasia/carcinoma, n (%)

Variables	Low-grade dysplasia (n = 226)	High-grade dysplasia/carcinoma (n = 149)	χ2	P value
Gender			6.114	0.013
Male	104 (46.0)	88 (59.1)
Female	122 (54.0)	61 (40.9)
Age (years)			0.268	0.605
< 60	74 (32.6)	45 (30.2)
≥ 60	152 (67.3)	104 (69.8)
Smoking			2.499	0.114
No	177 (78.3)	106 (71.1)
Yes	49 (21.7)	43 (28.9)
Alcohol drinking			3.743	0.053
No	187 (82.7)	111 (74.5)
Yes	39 (17.3)	38 (25.5)
Location			3.762	0.152
Right colon	109 (48.2)	72 (48.3)
Left colon	96 (42.5)	54 (36.2)
Rectum	21 (9.3)	23 (15.4)
Size (mm)			10.193	0.006
10-19 mm	128 (56.6)	61 (40.9)
20-29 mm	70 (31.0)	56 (37.6)
≥ 30 mm	28 (12.4)	32 (21.5)
LST subtype			27.866	0.000
G-H	67 (29.6)	35 (23.5)
G-M	79 (35.0)	79 (53.0)
NG-F	67 (29.6)	16 (10.7)
NG-PD	13 (5.8)	19 (12.8)
Resection method			11.534	0.001
EMR	50 (22.1)	13 (8.7)
ESD	176 (77.9)	136 (91.3)
Procedural characteristics
En bloc resection	218 (96.5)	143 (96.0)	0.059	0.808
R0 resection	215 (95.1)	135 (90.6)	2.960	0.085
Complications
Delayed bleeding	3 (1.3)	6 (4.0)	2.793	0.095
Perforation	10 (4.4)	9 (6.0)	0.487	0.485

LST: Laterally spreading tumor; G-H: Laterally spreading tumor granular homogeneous type; G-M: Laterally spreading tumor granular nodular mixed type; NG-F: Laterally spreading tumor non-granular flat elevated type; NG-PD: Laterally spreading tumor non-granular pseudo depressed type; EMR: Endoscopic mucosal resection; ESD: Endoscopic submucosal dissection.