Pancreato-hepatobiliary neuroendocrine tumors diagnosed through endoscopic ultrasound: Clinical characteristics and factors associated with high-grade lesions

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Jun 16, 2025 (publication date) through Jun 14, 2025

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Endosc. Jun 16, 2025; 17(6): 105904
Published online Jun 16, 2025. doi: 10.4253/wjge.v17.i6.105904

Table 2 The WHO neuroendocrine neoplasms classification for pancreato-biliary and gastrointestinal tract

Neuroendocrine neoplasm	Classification	Diagnostic criteria
Well-differentiated neuroendocrine tumors (NET)	NET, grade 1	< 2 mitoses/2 mm² and/or Ki67 < 3%
	NET, grade 2	2-20 mitoses/2 mm² and/or Ki67 3-20%
	NET, grade 3	> 20 mitoses/2 mm² and/or Ki67 > 20%
Poorly differentiated neuroendocrine carcinoma (NEC)	Small cell NEC	> 20 mitoses/2 mm² and/or Ki67 > 20% (often > 70%), and small cell cytomorphology
Poorly differentiated neuroendocrine carcinoma (NEC)	Large cell NEC	> 20 mitoses/2 mm² and/or Ki67 > 20% (often > 70%), and large cell cytomorphology

Citation: Tasneem AA, Luck NH, Mubarak M. Pancreato-hepatobiliary neuroendocrine tumors diagnosed through endoscopic ultrasound: Clinical characteristics and factors associated with high-grade lesions. World J Gastrointest Endosc 2025; 17(6): 105904
URL: https://www.wjgnet.com/1948-5190/full/v17/i6/105904.htm
DOI: https://dx.doi.org/10.4253/wjge.v17.i6.105904