Repeated hemorrhagic ulcers of the esophagus associated with acquired hemophilia A: A case report

Figure 1 Timeline of the patient’s clinical course. Regarding changes in treatment interventions, for endoscopic hemostasis, radiofrequency ablation was performed a total of 7 times at the previous hospital; however, it was difficult to stop bleeding from the esophageal ulcer. After the patient was transferred to our hospital, endoscopic hemostasis was attempted once, but the effect was insufficient. After the administration of the bypass hemostatic agent, a mixture of factors VIIa and X (Byclot^®) derived from the plasma, the esophageal bleeding stopped. Two weeks later, the patient developed intramuscular bleeding in another area, and Byclot^® was administered again, which stopped the bleeding. To prevent further bleeding, the administration of emicizumab was started, and no rebleeding occurred.