Advances in endoscopic dysplasia detection in inflammatory bowel disease

Table 7 Endoscopic techniques for dysplasia characterization in inflammatory bowel disease

Ref.	Study design	Techniques compared	Key findings
Bisschops et al[30], 2018	Prospective comparative study	HD CE vs HD NBI	CE had higher sensitivity (88%) than NBI (60%) for Kudo pit pattern-based dysplasia diagnosis; NPV was similar (89%)
Carballal et al[2], 2018	Large prospective cohort study	WLE with targeted biopsies using the pit pattern	Non-polypoid morphology, proximal location, and type III-V pit pattern were associated with dysplasia; supports the pit pattern as a diagnostic adjunct
van den Broek et al[26], 2011	Prospective study	AFI, NBI, WLE	AFI had the highest sensitivity and NPV for dysplasia characterization; the combined use improved detection
Vleugels et al[34], 2018	Pre-specified analysis of FIND-UC RCT	Trimodal (AFI, NBI, WLE) vs CE	CE had slightly better sensitivity (82% vs 77%) for dysplasia; both had high NPV (> 94%); AFI alone had the best sensitivity (92%)

HD: High definition; CE: Chromoendoscopy; NBI: Narrow band imaging; WLE: White light endoscopy; AFI: Autofluorescence imaging; PDD: Photodynamic diagnosis; NPV: Negative predictive value; RCT: Randomized controlled trial; IBD: Inflammatory bowel disease.