Advances in endoscopic dysplasia detection in inflammatory bowel disease

Table 4 Studies comparing dye-based and virtual chromoendoscopy techniques for dysplasia detection in inflammatory bowel disease

Ref.	Techniques compared	Study design	Key findings
Bisschops et al[30], 2018	HD CE vs NBI	Multicenter RCT	No significant difference in dysplasia detection (21.2% vs 21.5%); NBI had shorter procedure time
Pellisé et al[31], 2011	HR CE vs HR NBI	Randomized crossover study	NBI is less time-consuming, but CE had a lower miss rate for intraepithelial neoplasia; not statistically significant
González-Bernardo et al[13], 2021	CE vs i-SCAN (VCE)	RCT	No significant difference in dysplasia detection rate; CE required more procedure time
Jans et al[32], 2024	CE vs i-SCAN OE	RCT	Both techniques are comparable in dysplasia detection; CE offered slightly better lesion characterization
Efthymiou et al[33], 2013	CE vs NBI	RCT	Dysplasia detection rates were similar; NBI had fewer false positives and was faster
Vleugels et al[34], 2018	CE vs AFI	RCT (FIND-UC trial)	CE had higher specificity and fewer false positives than AFI; no difference in dysplasia detection

CE: Chromoendoscopy; NBI: Narrow band imaging; VCE: Virtual chromoendoscopy; i-SCAN OE: I-SCAN optical enhancement; AFI: Autofluorescence imaging; HD: High definition; HR: High resolution; RCT: Randomized controlled trial; IBD: Inflammatory bowel disease.