Impact of periampullary diverticulum on the incidence of post-endoscopic retrograde cholangiography pancreatitis

Table 4 Subgroup analyses of the association between periampullary diverticulum and incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis, n (%)

Subgroup	Total	Event	Crude OR (95%CI)	Crude P value	Adjusted OR (95%CI)	Adjusted P value	P value for interaction
Males							0.797
No	212	7 (3.3)	1.01		1.01
Yes	99	11 (11.1)	3.66 (1.37-9.75)	0.009	3.74 (1.38-10.1)	0.009
Females
No	220	10 (4.5)	1.01		1.01
Yes	84	14 (16.7)	4.2 (1.79-9.88)	0.001	4.49 (1.78-11.33)	0.002
Without hypertension							0.162
No	245	13 (5.3)	1.01		1.01
Yes	96	13 (13.5)	2.8 (1.25-6.27)	0.013	2.52 (1.07-5.92)	0.034
With hypertension
No	187	4 (2.1)	1.01		1.01
Yes	87	12 (13.8)	7.32 (2.29-23.42)	0.001	7.64 (2.36-24.71)	0.001
Without diabetes mellitus							0.398
No	367	16 (4.4)	1.01		1.01
Yes	151	21 (13.9)	3.54 (1.79-7)	< 0.001	3.46 (1.71-6.99)	0.001
With diabetes mellitus
No	65	1 (1.5)	1.01		1.01
Yes	32	4 (12.5)	9.14 (0.98-85.53)	0.052	11.54 (1.15-116.01)	0.038
Without coronary heart disease							0.91
No	373	15 (4)	1.01		1.01
Yes	153	21 (13.7)	3.8 (1.9-7.59)	< 0.001	3.71 (1.79-7.67)	< 0.001
With coronary heart disease
No	59	2 (3.4)	1.01		1.01
Yes	30	4 (13.3)	4.38 (0.75-25.48)	0.1	3.59 (0.6-21.49)	0.162
Without hepatitis							0.374
No	405	17 (4.2)	1.01		1.01
Yes	168	24 (14.3)	3.8 (1.99-7.29)	< 0.001	3.95 (2.01-7.75)	< 0.001
With hepatitis
No	27	0 (0)	1.01		1.01
Yes	15	1 (6.7)	02	*	7.82 (0.65-94.5)	0.105
With history of cholecystectomy							0.485
No	346	15 (4.3)	1.01		1.01
Yes	140	23 (16.4)	4.34 (2.19-8.59)	< 0.001	4.43 (2.17-9.04)	< 0.001
Without history of cholecystectomy
No	86	2 (2.3)	1.01		1.01
Yes	43	2 (4.7)	2.05 (0.28-15.07)	0.481	2.01 (0.27-14.96)	0.495
Guidewires enter the pancreatic duct							0.315
No	67	8 (11.9)	1.01		1.01
Yes	47	11 (23.4)	2.25 (0.83-6.13)	0.112	1.93 (0.66-5.67)	0.233
Guidewires did not enter the pancreatic duct
No	365	9 (2.5)	1.01		1.01
Yes	136	14 (10.3)	4.54 (1.92-10.75)	0.001	5.02 (2.06-12.26)	< 0.001
Without hyperamylasemia							0.419
No	355	17 (4.8)	1.01		1.01
Yes	136	24 (17.6)	4.26 (2.21-8.22)	< 0.001	4.27 (2.18-8.38)	< 0.001
With hyperamylasemia
No	77	0 (0)	1.01		1.01
Yes	47	1 (2.1)	02	02	5.91 (0.52-67.8)	0.158

¹1.0 was used as the reference group, indicates the reference category.

²Statistical value (the crude odds ratio, its 95% confidence interval, and the corresponding crude P value) could not be calculated due to the characteristics of the raw data.

OR: Odds ratio; CI: Confidence interval.