Impact of gut microbiome on outcomes following endoscopic interventions in gastrointestinal disease

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Endosc. Nov 16, 2025; 17(11): 110207
Published online Nov 16, 2025. doi: 10.4253/wjge.v17.i11.110207

Table 2 Key metabolites and their roles in mucosal healing

Metabolite	Source microbes	Role in healing
Butyrate	Faecalibacterium prausnitzii, Bacteroides	Fuels colonocytes, regulates immune cells, maintains epithelial integrity
SCFAs (acetate, propionate)	Fermentative bacteria (e.g., Bacteroides)	Supports tight junctions, immune modulation
LPS	Proteobacteria, pathogenic strains	Triggers cytokine release, exacerbates inflammation

SCFAs: Short chain fatty acids; LPS: Lipopolysaccharides.

Citation: Agrawal H, Agarwal N, Gupta N. Impact of gut microbiome on outcomes following endoscopic interventions in gastrointestinal disease. World J Gastrointest Endosc 2025; 17(11): 110207
URL: https://www.wjgnet.com/1948-5190/full/v17/i11/110207.htm
DOI: https://dx.doi.org/10.4253/wjge.v17.i11.110207

Agrawal H, Agarwal N, Gupta N. Impact of gut microbiome on outcomes following endoscopic interventions in gastrointestinal disease. World J Gastrointest Endosc 2025; 17(11): 110207 [PMID: 41256293 DOI: 10.4253/wjge.v17.i11.110207]

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