Endoscopic resection of colitis-associated neoplasia: A scoping review

Table 5 Summary of outcomes from studies using endoscopic mucosal resection, endoscopic submucosal dissection, and hybrid techniques in ulcerative colitis-associated neoplasia

	Alipouriani et al[31], 2025	Hirai et al[32], 2023	Smith et al[33], 2008	Pal et al[26], 2022
Setting	Tertiary United States center	14 Japanese centers	United Kingdom single center	Tertiary center, India
Patients (n)	50	336	67	6
Lesions	ESD (n = 38), ESD + EMR (n = 11), EMR (n = 1)	ESD (n = 96), EMR (n = 142)	Hybrid ESD-assisted EMR	EMR (n = 5), ESD (n = 1)
En bloc resection (%)	68%	ESD: 97%, EMR: 89%	ESD-EMR: 78%	83.3%
R0 resection (%)	Not specified	Not specified	94% (en bloc subset)	83.3%
Perforation rate	2%	ESD: 6.3%, EMR: 0%	3%	None
Recurrence (%)	18%	Local: 2.7%, metachronous: 6.1%	Local: 7%, metachronous: 0%	1 case residual, treated
Follow-up duration	3 years (median)	34.7 months (median)	18 months (median)	Short-term
Key Findings	ESD and hybrid feasible with minimal complications; recurrence similar across groups	Large multicenter validation of ER in UC; higher perforation with ESD; no difference in recurrence	Hybrid ESD-EMR enables resection in fibrotic ALMs; high R0 and low recurrence	Combined resection feasible in Indian setting; R0 achieved in 5/6; residual lesion managed endoscopically

EMR: Endoscopic mucosal resection; ESD: Endoscopic submucosal dissection; UC: Ulcerative colitis; ALMs: Adenoma like mass; R0: Histologically complete resection.