Evaluating the prognostic efficacy of biomarkers in pancreatic cyst fluid

Table 3 Diagnostic ability of various cystic fluid biomarkers

Molecular marker	Diagnostic ability of mucinous cysts	AUC for mucinous cysts diagnosis (range)	SENS for mucinous cysts diagnosis (range)	SPEC for mucinous cysts diagnosis (range)	Diagnostic ability discriminating malignant from non -malignant cysts	Simplicity of use/availability
Cystic CEA	Moderate	0.633-0924	48%-95.4%	82%-98%	-	Moderate
Cystic glucose	Moderate	0.870-0980	89%-95%	78%-95.1%	-	Good
Cystic amylase	-	-	-	-	Inadequate	Moderate
KRAS	Moderate	-	61%	99%	Inadequate	Inadequate
GNAS	Moderate	-	39%-90%	100%	Inadequate	Inadequate
KRAS + GNAS	Moderate	-	79%	98%	Inadequate	Inadequate

CEA: Carcinoembryonic antigen; AUC: Area under the curve; SENS: Sensitivity; SPEC: Specificity.