Endoscopic management and outcome of non-variceal bleeding in patients with liver cirrhosis: A systematic review

Table 2 Main characteristics of studies including patients with cirrhosis and acute upper gastrointestinal bleeding due to peptic ulcers

Ref.	Patients (n)	Cirrhotic patients with NVAGIB (n)	Non-variceal bleeding source: peptic ulcer/other (n)	Patients received endoscopic treatment (n)	Endoscopic treatment modality (n)	Failure to control bleeding, n (%)	Rebleeding, n (%)	Mortality, n (%)	Rescue therapy
Seo et al[18]	464	76	GU: 48; DU: 16; OL: 12	48	EC: 201	1/76 (1.3%)	2/76 (2.6%)	42 d: 11/76 (14.5%)	NR
González-González et al[22]	160	160	GU: 39; DU: 33; GU + DU: 9; EU: 3	43	EI: 7; BICAP EC: 6; CT: 30	NR	3/160 (1.9%)	In-hospital: 22 (13.8%)	S: 0
Rudler et al[23]	203	29	DU: 19; GU: 7; MU: 3	20	EI: 9; EI + HC: 11	NR	2/29 (7%)	30 d: 1/29 (3%)	AE: 3; S: 0
Morsy et al[24]	532	93	DU: 25; EU: 5; GU: 3	42	EI: 23; APC: 19	NR	4/93 (4.3%)	In-hospital: 13/93 (14%)	NR
Yang et al[19]	210	210	GU: 133; DU: 66; GU + DU: 11	210	EI: 80; APC: 41; HC: 13; EI + APC: 36; EI + HC: 40	7 (3.3%)	47 (22.4%)	In-hospital: 37/210 (17.6%)	NR
Kuo et al[20]	235	235	GU:146; DU: 73; GU + DU: 16	235	EI: 84; APC: 50; HC: 20; CT: 81	8 (3.4%)	48 (20.4%)	In-hospital: 40/235 (17%)	NR
Ardevol et al[21]	790	144	DU: 79; GU: 62; SU: 3	88	EI: NR; Multipolar EC: NR; HC: NR; EIS: NR	14 (10%)	15 (10%)	6 wk: 24/144 (17%)	SET: 11; AE: 3; S: 2

¹Endoscopic treatment modality only mentioned for 20/48 patients;

NVAGIB: Non-variceal acute gastrointestinal bleeding; GU: Gastric ulcer; DU: Duodenal ulcer; EU: Esophageal ulcer; OL: Other lesions; MU: Multiple ulcers; EC: Electrocoagulation; EI: Epinephrine injection; HC: Hemoclips; CT: Combination therapy; APC: Argon plasma coagulation; EIS: Endoscopic injection sclerotherapy; NR: Not reported; S: Surgery; AE: Arterial embolisation; SET: Second endoscopic treatment.