Gastrointestinal amyloidosis: A focused review

doi:10.4253/wjge.v13.i1.1

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Jan 16, 2021 (publication date) through Apr 25, 2024

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World Journal of Gastrointestinal Endoscopy

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1948-5190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Endosc. Jan 16, 2021; 13(1): 1-12
Published online Jan 16, 2021. doi: 10.4253/wjge.v13.i1.1

Table 3 Management of gastrointestinal amyloidosis based on the amyloid protein

Gastrointestinal amyloidosis	AL amyloidosis	AA amyloidosis	Hereditary amyloidosis	Dialysis-related amyloidosis
Treatment strategy	Systemic: Eligible: Autologous stem cell transplantation (ASCT) for plasma cell dyscrasias. Non-eligible: No standard protocol; combination of Bortezomib, Melphalan and Dexamethasone has shown improved survival. Localized: Observation or localized surgical excision	Chronic inflammatory conditions: Biologics (anti-TNF antibodies, humanized anti-IL6 receptor antibody) and immunosuppressants. Familial mediterranean fever: Colchicine.	Liver production of transthyretin: Orthotopic liver transplantation (OLT). Disease modifying therapy: Transthyretin stabilizers (Tafamidis and Diflunisal), Doxycycline, Patisiran and Inotersen may be used on case-to-case basis	Prevention: Removal of plasmatic β2-microglobulin (Aβ₂M) through hemodialysis or peritoneal dialysis. Early renal transplant

Citation: Dahiya DS, Kichloo A, Singh J, Albosta M, Wani F. Gastrointestinal amyloidosis: A focused review. World J Gastrointest Endosc 2021; 13(1): 1-12
URL: https://www.wjgnet.com/1948-5190/full/v13/i1/1.htm
DOI: https://dx.doi.org/10.4253/wjge.v13.i1.1