Endoscopic ultrasound-guided sampling of solid pancreatic masses: the fine needle aspiration or fine needle biopsy dilemma. Is the best needle yet to come?

Table 2 Published comparative studies regarding fine needle biopsy needles performance in terms of diagnostic yield

Ref	Study design	N°Lesions,pan-creatic	Rose	Needles	Gauge	Diagnostic yield, %	Sample adequacy, %	Comments
[64]	Cohort	(201)	No	Opposing bevel vs reverse bevel	22-25 vs 20-22-25	71 vs 90	87 vs 99	Opposing bevel needle resulted superior
[65]	Cohort	194 (100)	Only in 12% of cases	Franseen vs fork tip	22	64 vs 85	The use of ROSE is a confounding factor	Fork tip seems superior, but the study lack of methodology
[66]	RCT	(50)	Yes	Franseen vs fork tip	22	> 90%, equivalent	94 vs 98	Equivalent
[67]	Cohort	(66)		Procore	22 vs 25	87.5 vs 82.1	98 vs 95	Equivalent

RCT: Randomized clinical trial; ROSE: Rapid on site evaluation.