Severity of gastric mucosal atrophy affects the healing speed of post-endoscopic submucosal dissection ulcers

Table 3 Univariate analysis of factors preventing healing of ulcers after endoscopic submucosal dissection

	Reduction rate over 90% at 4 wk		Reduction rate 100% at 8 wk
Variable	Not achieved (n = 45)	P value	Not achieved (n = 16)	P value
Age (yr)	1.004 (0.963-1.048)	0.841	1.058 (0.987-1.135)	0.113
Gender (female vs male)	1.127 (0.491-2.588)	0.777	3.583 (1.218-10.545)	0.021
Helicobacter pylori	1.088 (0.525-2.255)	0.820	3.111 (0.945-10.244)	0.053
Lansoprazole vs vonoprazan	1.108 (0.493-2.488)	0.804	0.418 (0.089-1.956)	0.210
Anti-coagulants	1.148 (0.436-3.018)	0.780	1.958 (0.561-6.832)	0.231
CYP2C19 type (EM vs IM/PM)	1.084 (0.635-1.850)	0.768	0.921 (0.420-2.020)	0.838
Atrophy (Kyoto A0+A1 vs Kyoto A2)	6.047 (1.334-27.403)	0.010	3.132 (0.390-25.163)	0.233
Tumor located in upper and middle third (vs lower third)	0.465 (0.211-1.026)	0.055	1.361 (0.471-3.934)	0.568
Mean procedure time (min)	1.009 (1.002-1.017)	0.018	1.001 (0.991-1.011)	0.871
Mean resected ulcer area (mm2)	1.001 (1.000-1.001)	0.032	1.001 (1.000-1.001)	0.013

EM: Extensive metabolizer; IM: Intermediate metabolizer; PM: Poor metabolizer.