长链非编码RNA SNHG16在消化系统肿瘤中作用机制研究进展

表2 SNHG16在消化系统肿瘤中的临床病理特征

肿瘤类型	临床特征	参考文献
GC	Invasion depth, lymph node metastasis, TNM stage, histological differentiation	[7]
GC	Tumor size, TNM stage, poor survival	[8]
GC	Invasion depth	[11]
CRC	TNM stage	[13]
CRC	Metastasis, lymph node	[14]
CRC	LV1, PNI, TNM stage, lymph node, metastasis, distant metastasis, poor prognosis	[19]
ESCC	Tumor stage, lymph nodes metastasis, clinical stage, poor survival, poor prognosis	[21]
ESCC	Tumour differentiation, T stage	[24]
PC	Poor prognosis	[26]
PC	Gemcitabine resistance	[28]
HCC	Tumor size, AFP level, PVTT, metastasis, poor survival, sorafenib resistance	[31]
HCC	Multiple tumors, macrovascular invasion, poor prognosis	[32]
HCC	Serum AFP level, poor prognosis	[33]
HCC	Tumor size, TNM stage, ALT level, HBV DNA level	[34]
HCC	Tumor size, lymph node status, TNM stage and poor prognosis	[36]
HCC	Poor prognosis	[37]
HCC	Tumour diameter, tumour thrombus, tumour satellites, poor prognosis	[38]
HCC	Sorafenib resistance	[39]
HCC	Tumor size, TNM stage, vascular invasion, sorafenib resistance	[40]
HCC	Poor prognosis	[44]

SNHG16: 小核仁RNA宿主基因16; GC: 胃癌; CRC: 结直肠癌; ESCC: 食管鳞癌; PC: 胰腺癌; HCC: 肝细胞癌; LVI: 淋巴血管侵袭; PNI: 神经周围侵犯; PVTT: 门静脉肿瘤血栓; AFP: 甲胎蛋白; TNM: 肿瘤, 淋巴结, 转移; HBV: 乙型肝炎病毒; ALT: 丙氨酸转氨酶.