circRNAs在消化系肿瘤化疗耐药中的研究进展

表2 与消化系肿瘤化疗耐药相关的circRNAs

癌症	circRNA	表达	促进/抑制耐药	机制	细胞系	化疗药物	参考文献
肝癌	circRNA-SORE	↑	促进	YBX1	HepG2、LM3和SKHep1	索拉非尼	[41]
	circRNA-SORE	↑	促进	miR-103a-2-5p和miR-660-3p/Wnt/β-catenin	HepG2、LM3和SKHep1	索拉非尼	[22]
	circFN1	↑	促进	miR-1205/E2F1	Huh7和HepG2	索拉非尼	[42]
	circFOXM1	↑	促进	miR-1324/MECP2	HepG2 和 Huh7	索拉非尼	[43]
	circARNT2	↑	促进	miR-155-5p/PDK1	Hep3B和Huh7	顺铂	[45]
	circ_0031242	↑	促进	miR-924/POU3F2	HuH7和SNU387	顺铂	[46]
	circRNA_102272	↑	促进	MiR-326/RUNX2	HepG2和HuH7	顺铂	[47]
	circFBXO11	↑	促进	miR-605/FOXO3/ABCB1	HepG2	奥沙利铂	[25]
	circRNA_101505	↓	抑制	miR-103/NOR1	Hep3B和Huh7	顺铂	[48]
	circ_0003418	↓	抑制	Wnt/β-Catenin	Hep3B和Huh7	顺铂	[49]
	circFoxo3	↑	促进	miR-199a-5p/ABCC1	SKHEP-1和HepG2	阿霉素	[50]
	circular PTGR1	↑	促进	miR-129-5p/ABCC1	Hep3B和Huh7	5-氟尿嘧啶	[51]
	circ_0003998	↑	促进	miR-218-5p/EIF5A2	Huh7和HCCLM3	阿霉素	[52]
胃癌	circVAPA	↑	促进	miR-125b-5p/STAT3	SGC7901和HGC27	顺铂	[56]
	circAKT3	↑	促进	miR-198/PIK3R1	SGC7901	顺铂	[27]
	circFAM73A	↑	促进	miR-490-3p /HMGA2	BGC823和SGC7901	顺铂	[32]
	circDONSON	↑	促进	miR-802/BMI1	AGS和HGC-27	顺铂	[57]
	circCCDC66	↑	促进	miR-618 /BCL2	BGC823和SGC7901	顺铂	[58]
	circFN1	↑	促进	miR-182-5p	SGC7901	顺铂	[59]
	hsa_circ_0081143	↑	促进	miR-646/CDK6	SGC7901和MGC803	顺铂	[60]
	circ-PVT1	↑	促进	miR-30a-5p/YAP1	HGC-27和AGS	顺铂	[61]
	circPVT1	↑	促进	miR-152-3p/HDGF/PI3K/AKT	AGS和HGC-27	顺铂	[62]
	circ_0026359	↑	促进	miR-1200/POLD4	SGC-7901和MKN-45	顺铂	[63]
	circ_0032821	↑	促进	miR-515-5p/SOX9	HGC-27和AGS	奥沙利铂	[64]
	hsa_circ_0000144	↑	促进	miR-502-5p/ADAM9	AGS和MKN45	奥沙利铂	[65]
	circCUL2	↓	抑制	miR-142-3p/ROCK2	AGS和SGC-7901	顺铂	[66]
	circMCTP2	↓	抑制	miR-99a-5p/MTMR3	BGC823和SGC7901	顺铂	[67]
	hsa_circ_0001546	↓	抑制	miR-421/ATM/Chk2/p53	HGC-27	奥沙利铂	[68]
	circRACGAP1	↑	促进	miR-3657/ATG7	BGC-823和HGC-27	阿帕替尼	[34]
	circ-PVT1	↑	促进	miR-124-3p/ZEB1	MGC-803和AGS	紫杉醇	[29]
	circNRIP1	↑	促进	miR-138-5p/HIF-1α	SGC-7901和 BGC-823	5-氟尿嘧啶	[69]
	circMTHFD2	↑	促进	miR-124/FDZ5/MDR-1	MGC-803	培美曲塞	[70]
	circHECTD1	↑	促进	miR-137/PBX3	AGS和HGC-27	Diosbulbin-B	[71]
结直肠癌	circ_0007031	↑	促进	miR-133b/ABCC5	HCT116和SW480	5-氟尿嘧啶	[75]
	circ-PRKDC	↑	促进	miR-375/FOXM1/Wnt/β-catenin	SW620和SW480	5-氟尿嘧啶	[76]
	circ_0032833	↑	促进	miR-125-5p/MSI1	HCT116	5-氟尿嘧啶和奥沙利铂	[77]
	circDDX17	↓	抑制	miR-31-5p/KANK1	HCT116和SW480	5-氟尿嘧啶	[78]
	hsa_circ_0005963	↑	促进	miR-122/PKM2	HCT116和SW480	奥沙利铂	[24]
	circ-CCDC66	↑	促进	--	HCT116和HT-2	奥沙利铂	[79]
	hsa_circ_0079662	↑	促进	miR-324-5p/TNF-α	HCT116	奥沙利铂	[80]
	circ_0071589	↑	促进	MiR-526b-3p/KLF12	HCT116和LOVO	顺铂	[81]
	circCSPP1	↑	促进	miR-944/FZD7	LoVo和HCT116	阿霉素	[82]
	hsa_circ_001680	↑	促进	miR-340/BMI1	SW480和HCT116	伊立替康	[83]
食管癌	circ_0006168	↑	促进	miR-194-5p/JMJD1C	ECA109和KYSE150	紫杉醇	[87]
	circPSMC3	↓	抑制	miR-10a-5p/PTEN	TE1和KYSE450	吉非替尼	[88]
胰腺癌	circHIPK3	↑	促进	miR-330-5p/RASSF1	PANC-1和SW-1990	吉西他滨	[91]