Cyp4 A2, Apoa1, ANXA2及DPYD为金雀异黄酮抗肝纤维化大鼠的关键蛋白

表1 金雀异黄酮作用肝纤维化大鼠后肝组织中差异表达的蛋白质

序号	蛋白收录号	基因名称	蛋白质名称	114:113
1	P04906	GSTP1	Glutathione S-transferase P	2.331
2	G3V786	G3V786	Protein Akr1b8	1.722
3	Q5RJK5	Q5RJK5	Chromobox homolog 3	2.549
4	Q5XFV4	Q5XFV4	Fabp4 protein	1.852
5	Q6B345	S100a11	Protein S100-A11	2.086
6	P14480	Fgb	Fibrinogen beta chain	2.508
7	D3ZY96	D3ZY96	Neutrophilic granule protein	2.771
8	P01048	Map1	T-kininogen 1	1.668
9	P50116	S100A9	Protein S100-A9	1.254
10	P02680	Fgg	Fibrinogen gamma chain	2.065
11	Q63279	Krt19	Keratin, type I cytoskeletal 19	3.043
12	D3ZC07	D3ZC07	Protein Pkn3	3.682
13	M0R4B8	M0R4B8	Pyruvate kinase	3.612
14	Q05BA4	Q05BA4	Myadm protein	1.538
15	Q6PDW1	Q6PDW1	40S ribosomal protein S12	1.508
16	M0R9G2	M0R9G2	Protein L	3.203
17	P31977	EZR	Ezrin	3.015
18	A0JPN2	Slc39a4	Zinc transporter ZIP4	2.079
19	6UPE1	Etfdh	Electron transfer flavoprotein-ubiquinone	2.968
20	M0R9D5	M0R9D5	Protein Ahnak	2.959
21	D3ZQN7	D3ZQN7	Protein Lamb1	2.892
22	B0BNA5	COTL1	Coactosin-like protein	2.824
23	P04639	APOA1	Apolipoprotein A-I	2.689
24	P68255	Ywhaq	14-3-3 protein theta	1.672
25	G3V6H9	G3V6H9	Nucleosome assembly protein 1-like 1	1.667
26	Q9Z144	Lgals2	Galectin-2	2.651
27	G3V9M6	G3V9M6	Fibrillin 1, isoform	1.633
28	P62890	RPL30	60S ribosomal protein L30	2.625
29	Q5U216	DDX39A	ATP-dependent RNA helicase	3.558
30	Q5U2T9	Q5U2T9	FK506 binding protein 5	2.554
31	Q56B11	PELP1	Proline, glutamic acid and leucine-rich protein 1	2.535
32	G3V6C2	G3V6C2	Protein Hgd	0.364
33	Q5BK21	Q5BK21	Protein Tm7sf2	0.664
34	P33273	Cyp2c24	Cytochrome P450 2C24	0.263
35	A0A096MKG	Mnadk	NAD kinase 2, mitochondrial	0.462
36	Q5HZY2	SAR1B	GTP-binding protein	0.462
37	P07150	ANXA1	Annexin A1	0.462
38	Q920D2	Dhfr	Dihydrofolate reductase	0.462
39	P20817	Cyp 4a2	Cytochrome P450 4A2	0.262
40	Q66HK8	Q66HK8	Cytochrome P450 4F1	0.662
41	Q7TP52	CMBL	Carboxymethylenebutenolidase homolog	0.661
42	P97519	HMGCL	Hydroxymethylglutaryl-CoA lyase	0.359
43	F1LZJ4	F1LZJ4	Hydroxypyruvate isomerase	0.559
44	M0RC77	M0RC77	Kynurenine formamidase	0.558
45	F1M0Q9	F1M0Q9	Protein Pm20d1 (Fragment)	0.457
46	M0RBL9	M0RBL9	Protein Vwa8 (Fragment)	0.557
47	Q5RJR8	Lrrc59	Leucine-rich repeat-containing protein 59	0.657
48	P05544	Serpina3l	Serine protease inhibitor A3L	0.256
49	P97524	Slc27a2	Very long-chain acyl-CoA synthetase	0.156
50	B0BNE5	Esd	S-formylglutathione hydrolase	0.155
51	P41562	Idh1	Isocitrate dehydrogenase [NADP] cytoplasmic	0.355
52	M0R5Y9	M0R5Y9	Protein Zbtb8os	0.354
53	D4A5G8	D4A5G8	Pyruvate dehydrogenase E1	0.554
54	D4AB01	D4AB01	Histidine triad nucleotide binding protein 2	0.453
55	Q66HG4	GALM	Aldose 1-epimerase	0.453
56	Q07936	ANXA2	Annexin A2	0.653
57	D3ZTP0	D3ZTP0	Protein Aldh1l2	0.653
58	D3ZF07	D3ZF07	Protein RGD1562402	0.452
59	O89000	DPYD	Dihydropyrimidine dehydrogenase [NADP(+)]	0.652
60	Q06884	Q06884	Cytochrome P450 3A1	0.552
61	B5DFH4	B5DFH4	Papss2 protein	0.252
62	Q7TPA1	Q7TPA1	Ab1-114	0.251
63	Q5BJZ3	Q5BJZ3	Nicotinamide nucleotide transhydrogenase	0.151