MK-886与塞来昔布小剂量联合对小鼠结肠癌的抑制作用

表1 RT-PCR法检测小鼠结肠癌裸鼠移植瘤组织中ICAM-1/actin、VEGF/actin r值 (mean±SD)

分组	ICAM-1 mRNA表达(ICAM-1/actin)	VEGF-1 mRNA表达(VEGF/actin)
1 对照组	0.90±0.049	0.92±0.083
2 [10 mg/(kg·d)+100 mg/(kg·d)]	0.33±0.201a	0.48±0.167a
3 [10 mg/(kg·d)+50 mg/(kg·d)]	0.40±0.118a	0.54±0.109a
4 [5 mg/(kg·d)+100 mg/(kg·d)]	0.36±0.132a	0.43±0.061a
5 [5 mg/(kg·d)+50 mg/(kg·d)]	0.23±0.104b	0.34±0.353b

^aP<0.05,

^bP<0.01 vs 对照组; ICAM-1: 细胞间黏附分子-1; VEGF: 血管内皮生长因子.