生物信息学方法对人类和小鼠共同肝癌相关基因的筛选

表2 人类与小鼠的共同差显基因

基因	基因名称	表达水平
itm2b	integral membrane protein 2B
abcc5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5
arf3	ADP-ribosylation factor 3
aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)
cdc20	cell division cycle 20 homolog (S.cerevisiae)	上调
cttn	cortactin; predicted gene 8786
ddx39	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
dnm1l	dynamin 1-like
fabp4	fatty acid binding protein 4, adipocyte	上调
gnb1	guanine nucleotide binding protein (G protein), beta 1
golm1	golgi membrane protein 1	上调
gpr56	G protein-coupled receptor 56
ier5	immediate early response 5
itga3	integrin alpha 3
itgb1	integrin beta 1 (fibronectin receptor beta)
itm2c	integral membrane protein 2C
itpr3	inositol 1,4,5-triphosphate receptor 3
klf6	Kruppel-like factor 6
lmna	lamin A
lrrc59	leucine rich repeat containing 59
ly6d	lymphocyte antigen 6 complex, locus D	上调
map4k4	mitogen-activated protein kinase kinase kinase kinase 4
meox1	mesenchyme homeobox 1
nek2	NIMA (never in mitosis gene a)-related expressed kinase 2
rac1	RAS-related C3 botulinum substrate 1
scn8a	sodium channel, voltage-gated, type VIII, alpha
slc1a4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
tagln2	transgelin 2
tgfbr2	transforming growth factor, beta receptor II
tmc6	transmembrane channel-like gene family 6
tpm1	tropomyosin 1, alpha
trib3	tribbles homolog 3 (Drosophila)
tspan8	tetraspanin 8	上调
wsb2	WD repeat and SOCS box-containing 2
ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; predicted gene 4202
crbn	cereblon
abat	4-aminobutyrate aminotransferase
acsl1	acyl-CoA synthetase long-chain family member 1
akap1	A kinase (PRKA) anchor protein 1
cbs	cystathionine beta-synthase
cxcl12	chemokine (C-X-C motif) ligand 12	下调
gas1	growth arrest specific 1	下调
ghr	growth hormone receptor
gnmt	glycine N-methyltransferase	下调
igfals	insulin-like growth factor binding protein, acid labile subunit	下调
masp1	mannan-binding lectin serine peptidase 1
paics	phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase; predicted gene 8445
pbld	phenazine biosynthesis-like protein domain containing
plxnc1	plexin C1; similar to plexin C1
sardh	sarcosine dehydrogenase
scnn1a	sodium channel, nonvoltage-gated 1 alpha
sirt3	sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)