亚硝胺诱导食管癌变早期基因差异表达与表观遗传修饰的关系

表1 部分基因差异表达的时段特点

基因	GenBank ID	Signal Log Ratio
		4 wk	8 wk	20 wk
Akt3	NM_011785	-	-	-
Met	NM_008591	-	-	-
Otc	NM_008769	-	-	-
Alb1	NM_009654	9.77	-	-
Mup1	NM_031188	21.88	-	-
Apoh	NM_013475	6.59	-	-
Rras	NM_009101	-	2.72	-
Ski	NM_011385	-	4.86	-
Frat2	NM_177603	-	2.59	-
Ets1	NM_011808	-	-	7.54
Fgr	A130081E08	-	-	2.55
Kit	NM_021099	-	-	2.71
Mafa	NM_194350	-	-	2.8
Mos	NM_020021	-	-	4.62
Mybl2	NM_008652	-	-	2.39
Rel	NM_009044	-	-	5.8
Bcl2	6030439K11	-	-	12.46
Braf	AK036798	-	-	5.46
Cdk2	NM_183417	-	-	3.00
Dntt	NM_009345	-	-	29.08
Plg	NM_008877	-	-	6.57
Sod1	AK080908	-	-	109.38
Crkl	NM_007764	-	2.31	3.80
Fos	NM_010234	-	15.84	10.52
Maff	NM_010755	-	32.53	22.96
Mafk	NM_010757	-	14.24	11.20
Mafg	NM_010756	-	2.17	3.11
Myb	NM_033597	-	9.42	18.64
Araf	1200013E08	-	8.40	14.80
Kras2	NM_021284	-	13.77	55.81
Mras	NM_008624	-	16.00	16.46
Nras	NM_010937	-	9.83	14.42
Src	NM_009271	-	2.40	3.46
Yes	NM_009535	-	2.70	10.42
Abl1	NM_009594	-	19.13	12.46
Crk	NM_133656	2.10	38.40	57.81
Junb	NM_008416	3.56	16.49	83.45
Jun	NM_010591	6.27	169.95	94.38
Myc	NM_010849	2.34	55.93	37.98
Raf1	NM_029780	2.36	85.86	74.91