乙型肝炎病毒准种异质性对干扰素应答性的影响

表1 慢性乙型肝炎患者的HBV DNA含量和准种异质性参数

Patient	HBV DNA load	Quasispecies Heterogeneity
n = 20	(copies/L)	Complexity	Clonal frequencies (%)	Diversity
Sustained Responsive (SR)
1	9.538×1010	6	3-48.5	0.926
2	2.547×1010	10	3-57.6	0.931
3	5.574×1010	9	3-51.5	0.927
4	4.896×109	11	3-45.5	0.942
5	2.760×1010	5	3-69.7	0.924
6	2.248×1011	10	3-60.6	0.933
7	3.436×109	8	3-72.7	0.923
8	2.987×1010	8	3-63.6	0.921
9	2.384×1011	9	3-57.6	0.918
10	2.162×1010	7	3-66.7	0.914
Nonresponsive(NR)
11	2.206×1010	27	3-12.1	0.897
12	1.158×1011	16	3-18.2	0.856
13	7.656×1010	16	3-18.2	0.869
14	1.769×107	18	3-21.2%	0.843
15	1.341×1011	18	3-21.2	0.895
16	1.069×1011	17	3-24.2	0.876
17	2.647×1010	16	3-21.2	0.855
18	4.518×109	13	3-18.2	0.847
19	1.197×1010	21	3-21.2	0.889
20	2.153×106	11	3-15.2	0.812
mean±SD
SR	7.27×1010 ±8.79×1010a	8.30±0.89b		0.926±0.008c
NR	5.16×1010±5.13×1010	18.5±2.68		0.869±0.016

^aP>0.05 vs NR;

^bP<0.001 vs NR;

^cP<0.001 vs NR.