文献综述
Copyright ©The Author(s) 2003.
世界华人消化杂志. 2003-01-15; 11(1): 65-71
在线出版 2003-01-15. doi: 10.11569/wcjd.v11.i1.65
表1 Fundamental pathways altered by DNA methylation in cancer
Pathway affectedGenes silenced by CpG island methylation
Cell cycle controlRb, p16(INK4a), p15, p14(ARF), p73
DNA damage repairMLH1, O6MGMT, GSTp, BRCA1
Inhibiting apoptosisDAP-kinase, Caspase-8, TMS1
Invasion tumor architectureE-cadherin, VHL, APC, LKB1, TIMP3, Thrombospondin1
Growth factor responseER, RARb, Androgen Receptor, Endothelin B Receptor, RASSF1A

引文著录: 周永宁, 徐采朴, 房殿春. CpG岛甲基化与胃肠道肿瘤. 世界华人消化杂志 2003; 11(1): 65-71