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A long-term goal in my research is to understand biological differences between the “normal”and “abnormal”. So, my research focus is cancer disease as it is one of very good windows for this goal. I expect that knowledge from my research model system will improve the understanding of basics of human diseases and provide therapeutic ways on the basis of differences. I have experienced molecular and cell biology, genetics and cancer biology. During BS and MS courses at the Department of Biology, Kyung Hee University, Seoul, Korea, my research focused on mitotic checkpoint mechanism in cell cycle event. As a researcher in Korea Institute of Science and Technology, Seoul, Korea, I conducted researches for neuronal cell differentiation. For PhD training at Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas, I studied roles of G-protein-coupled receptors (GPCRs) in cancer development and metastasis in terms of biochemistry, cell biology and mouse genetics. In that period, I could understand molecular and cellular mechanisms of cancer progression, and also experience cancer therapeutics. As a research associate at Department of Embryology, Carnegie Institution for Science, Johns Hopkins University, Baltimore, Maryland, I have tried to understand an origin of cancer in terms of combinatorial approaches of next generation sequencing technologies and mouse genetics. After those training courses, I joined the Department of Preventive Medicine, Kyung Hee University as a research professor. Projects there focused on a development of herbal medicines for cancer prevention and treatment. A new drug developed there is under clinical trials. Then, I joined the Korea National University of Transportation as an assistant professor. Now, my team investigates two topics: the origin of cancer and new drug development. Therefore, our project themes involve basic to translational researches. In brief, basic researches here are to define particular cancer cell groups in heterogeneous cancer population and to understand the origin of cancer. In vivo mouse model systems, in silico data analyses and in vitro cell biological tools are applied for those issues. Another research topic is to develop new drugs to treat cancer disease and to reveal biological markers for cancer diagnosis. In sum, my researches are expected to provide better knowledge for cancer disease and, in further, ways for cancer prevention and treatment.